By Qin Wang
This quantity of present subject matters in Membranes specializes in Adrenergic Receptor Biology, starting with a overview of previous successes and ancient views then extra discussing present basic tendencies in adrenic receptor stories in numerous contexts. This book additionally comprises discussions of the position and dating of adrenergic receptors to varied structures and ailments, constructing Adrenergic Receptor Biology as a wanted, functional reference for researchers.
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In light of our discussion above, it is possible that de novo complexes of GPCRs and their signaling partners assembled along the biosynthetic pathway, might be delivered to other endomembrane locations. Here, we focus on data indicating that these signaling systems might be found on the nuclear membrane. , 2008, reviewed in Goetzl, 2007; Boivin, Vaniotis, Allen, & Hebert, 2008). , 2009). , 2002; Wang, Wu, Ge, Ma, & Pei, 2003), GRKs (Yi, Gerdes, & Li, 2002; Johnson, Scott, & Pitcher, 2004; Yi, Zhou, Baker, Wang, Gerdes, & Li, 2005), A kinase anchoring proteins (AKAPs), and PKA (Sastri, Barraclough, Carmichael, & Taylor, 2005), among others, have been demonstrated to be trafficked to the nucleus and/or nuclear membrane.
In addition to recapitulating many of the features described in the other GPCR structures, this one held a special surprise in that the receptors were crystallized as ligand-bound dimers in five independent structures. The interface between the two monomers included TM V and VI. This result confirms a great deal of work which showed that GPCRs could form both homo- and heterodimeric structures. , 2007, 2008). However, it has also become clear in recent years that most if not all GPCRs can form dimers and possibly higher order structures (see Hebert & Bouvier, 1998; Bulenger, Marullo, & Bouvier, 2005; Prinster, Hague, & Hall, 2005; Milligan, 2009 for review).
An integrated view on the role of receptor mosaics at perisynaptic level: Focus on adenosine A(2A), dopamine D(2), cannabinoid CB(1), and metabotropic glutamate mGlu(5) receptors. J Recept Signal Transduct Res, 30, 355–369. Albert, P. , & Robillard, L. (2002). G protein specificity: Traffic direction required. Cell Signal, 14, 407–418. , Evans, R. , Peloquin, J. , & Vartian, B. , (2006). ORL1 receptor-mediated internalization of N-type calcium channels. Nat Neurosci, 9, 31–40. , & Dennis, M. (2000).
Advances in Adrenergic Receptor Biology by Qin Wang