Ahead of the Curve: David Baltimore's Life in Science - download pdf or read online

By Shane Crotty

ISBN-10: 0520225570

ISBN-13: 9780520225572

In Nineteen Fifties, Watson and Crick tested a so-called "central dogma" in molecular biology: DNA makes RNA, and RNA makes proteins. in spite of the fact that, round 1970, teams in US stumbled on the 1st exception of this rule. David Baltimore's and Howard Temin's groups came upon that RNA makes DNA! This unforeseen discovering of theirs in cancer-causing RNA viruses not just made this box up-side down, but in addition opened a brand new road referred to as "recombinant expertise" a decade later, for cloning genes and transfering any gene from one species to a different virtually at will. hence, Baltimore and Temin shared a Nobel prize in 1975. Baltimore's greatness prolonged past the technological know-how. He seen this international in an "unconventional" demeanour. He married a highly-talented chinese language biologist, and protested opposed to the hugely arguable US wars in Vietnam and Iraq. He has a very good knowledge which shall we examine from this well-written biography.

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Other professors privately agreed with him (and chortled behind closed doors), but his audacity shocked them. Yet although his manner could be abrasive and his arrogance was undeniable, his intelligence was di‹cult to ignore. Whimsically named by Francis Crick, the great sage of molecular biology, this principle is emblazoned in the minds of all molecular biology students: DNA RNA transcribe Protein translate The Central Dogma of molecular biology. The Central Dogma states, first, that all cells use DNA to store their genetic information.

E a s t e r vac at i o n At Easter vacation, Baltimore took a train from Philadelphia out to Great Neck. He spent a couple of days at home relaxing with his family, and then he borrowed the family car one morning and sprinted to Cold Spring Har*Rosalind Franklin died of cancer in 1958. Nobel Prizes are not given posthumously, but neither is a prize given to more than three individuals, so there will always be debate about whether Franklin would have received the prize had she lived. s wa rt h m o r e 27 bor.

Franklin’s laboratory consisted of Franklin himself, a technician, and Baltimore, all carefully pulling viruses apart, handling up to a trillion viruses a day. O‹cially, Franklin worked for Igor Tamm, the full professor who ran the animal virology laboratory. Rockefeller was arranged like a European university, with a full professor overseeing the work of a group of junior professors. Almost all other American universities allowed junior professors to run their own laboratories freely. Franklin worked hard, but it was Baltimore who spent nights working alone, one of a few scientists in the dark high-rise, tending to cells and protein extracts with stubborn vigilance.

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Ahead of the Curve: David Baltimore's Life in Science by Shane Crotty

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